Artificial intelligence in kidney transplantation: a 30-year bibliometric analysis of research trends, innovations, and future directions

Ren Fail. 2025 Dec;47(1):2458754. doi: 10.1080/0886022X.2025.2458754. Epub 2025 Feb 5.

Abstract

Kidney transplantation is the definitive treatment for end-stage renal disease (ESRD), yet challenges persist in optimizing donor-recipient matching, postoperative care, and immunosuppressive strategies. This study employs bibliometric analysis to evaluate 890 publications from 1993 to 2023, using tools such as CiteSpace and VOSviewer, to identify global trends, research hotspots, and future opportunities in applying artificial intelligence (AI) to kidney transplantation. Our analysis highlights the United States as the leading contributor to the field, with significant outputs from Mayo Clinic and leading authors like Cheungpasitporn W. Key research themes include AI-driven advancements in donor matching, deep learning for post-transplant monitoring, and machine learning algorithms for personalized immunosuppressive therapies. The findings underscore a rapid expansion in AI applications since 2017, with emerging trends in personalized medicine, multimodal data fusion, and telehealth. This bibliometric review provides a comprehensive resource for researchers and clinicians, offering insights into the evolution of AI in kidney transplantation and guiding future studies toward transformative applications in transplantation science.

Keywords: Bibliometric analysis; artificial intelligence; kidney transplantation; research hotspots; research trends.

Publication types

  • Review

MeSH terms

  • Artificial Intelligence* / trends
  • Bibliometrics*
  • Biomedical Research / trends
  • Humans
  • Kidney Failure, Chronic* / surgery
  • Kidney Failure, Chronic* / therapy
  • Kidney Transplantation* / statistics & numerical data
  • Kidney Transplantation* / trends
  • Machine Learning / trends

Grants and funding

This work was supported by a grant from Outstanding-Youth Cultivation Project for Union Foundation of Yunnan Applied Basic Research Projects [Project Number: 202201AY070001-044], Reserve Talents Project for Young and Middle-aged Academic and Technical Leaders of Yunnan Province [Project Number: 202205AC160062], 535 Talent Project of First Affiliated Hospital of Kunming Medical University [Project Number: 2022535D06], ‘ChengFeng’ Talent Training Project for Young and Middle-aged Academic Leaders and Reserve Talents of Kunming Medical University, and First-Class Discipline Team of Kunming Medical University ([Project Number: 2024XKTDPY03].