Sunscreens play an essential role in preventing skin cancer and photoaging. Nevertheless, concerns about their systemic absorption and environmental impacts persist. In this extensive literature review, we discuss the mechanisms of action, efficacy, and safety concerns related to sunscreen use, aiming to clarify current understandings and dispel prevalent myths. Despite ongoing debates regarding certain ingredients, the scientific consensus supports the use of sunscreens as a critical defense against ultraviolet (UV) radiation. Continued research is necessary to address safety concerns and to refine sunscreen formulations for optimal protection and minimal adverse effects. J Drugs Dermatol. 2025;24(2):142-146. doi:10.36849/JDD.8102.