Are beta-haemolytic streptococci involved in the pathogenesis of mesangial IgA-nephropathy?

Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:698-702.

Abstract

In retrospect we have found that 38 of 187 patients who fulfilled the criteria of mesangial IgA-nephropathy had possible acute glomerulonephritis at the onset of their disease. We have therefore studied anti-streptococcal antibodies (ASO and ADNAseB) prospectively. Forty-three per cent of the patients had ADNAseB greater than 800 units. Thirty-one per cent of the patients studied more than once had a fourfold or greater change in their ADNAseB titre. Thirty-three per cent of the patients had different groups of beta-haemolytic streptococci isolated from their throats. This indicates a possible role of beta-haemolytic streptococci in the pathogenesis of some cases of mesangial IgA-nephropathy.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Antibodies, Bacterial / analysis
  • Female
  • Glomerulonephritis, IGA / etiology*
  • Glomerulonephritis, IGA / immunology
  • Humans
  • Male
  • Streptococcal Infections / complications*
  • Streptococcus / immunology

Substances

  • Antibodies, Bacterial