Comprehensive Characterization and Bioactivity Assessment of Titanium Dioxide Nanoparticles Synthesized Using Chrysanthemum indicum Leaf Extract

Chem Biodivers. 2025 Jun;22(6):e202500244. doi: 10.1002/cbdv.202500244. Epub 2025 Feb 22.

Abstract

Bionanotechnology is the synthesis of environmentally friendly, biosynthetic nanomaterials by combining nanotechnology and biotechnology. Chrysanthemum indicum leaf extract in aqueous medium was used in the presented research work to produce titanium dioxide (TiO2) nanoparticles using a dependable and environmentally friendly method. The TiO2 nanoparticles derived from C. indicum were examined using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy. The diesel degradation activity of the TiO2 was evaluated, showing a significant reduction in diesel concentration (8%) after a 10-day incubation period. Furthermore, TiO2's hemolytic, antidiabetic, anti-inflammatory, and antioxidant properties were highlighted. Cubical-shaped nanoparticles with an even distribution were found by SEM analysis. When compared to standard drugs, the biosynthesized TiO2 nanoparticles demonstrated hemolytic potential, anti-inflammatory (albumin denaturation assay), antidiabetic, and antioxidant (2,2-diphenyl-1-picrylhydrazyl assay) properties. These results imply that TiO2 nanoparticles function as advantageous biological agents and are crucial to the bioremediation process. Due to the great potential of TiO2 nanoparticles, the notable characteristics of biosynthesized TiO2 nanoparticles suggest their potential useful applications in the biodegradation field in the future.

Keywords: Chrysanthemum indicum; biodegradation; biological potential; nanoparticles; titanium dioxide.

MeSH terms

  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants* / chemistry
  • Antioxidants* / pharmacology
  • Biphenyl Compounds / antagonists & inhibitors
  • Chrysanthemum* / chemistry
  • Chrysanthemum* / metabolism
  • Hemolysis / drug effects
  • Humans
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology
  • Nanoparticles* / chemistry
  • Particle Size
  • Picrates / antagonists & inhibitors
  • Plant Extracts* / chemistry
  • Plant Extracts* / pharmacology
  • Plant Leaves* / chemistry
  • Plant Leaves* / metabolism
  • Titanium* / chemistry
  • Titanium* / pharmacology

Substances

  • Titanium
  • titanium dioxide
  • Plant Extracts
  • Antioxidants
  • Hypoglycemic Agents
  • Biphenyl Compounds
  • Anti-Inflammatory Agents
  • Picrates
  • 1,1-diphenyl-2-picrylhydrazyl