Unravelling the interplay of nitrogen nutrition and the Botrytis cinerea pectin lyase BcPNL1 in modulating Arabidopsis thaliana susceptibility

Commun Biol. 2025 Feb 8;8(1):204. doi: 10.1038/s42003-025-07642-7.

Abstract

In this study, we investigated the interplay between nitrogen nutrition and the pectin degradation dynamics during Arabidopsis and Botrytis interaction. Our findings revealed that infected detached leaves from nitrogen-sufficient plants released more pectin lyase (PNL)-derived oligogalacturonides compared to nitrogen-deficient ones. We then focused on BcPNL1, the most highly expressed Botrytis PNL upon infection. Using mutant strains lacking BcPNL1, we observed reduced pathogenicity, a delay in germination and a lag in triggering the plant defense response. Additionally, in nitrogen-sufficient detached leaves, the elevated expression of jasmonic acid repressor genes observed upon infection with the wild-type strain was abolished with the mutants. These results linked the increased production of BcPNL-derived products to the increased expression of jasmonic acid repressor genes, contributing partially to the higher susceptibility of nitrogen-sufficient detached leaves. These findings could lay the foundation for new strategies aimed at reconciling both crop resistance to pathogens and the improvement of nitrogen nutrition.

MeSH terms

  • Arabidopsis Proteins* / genetics
  • Arabidopsis Proteins* / metabolism
  • Arabidopsis* / genetics
  • Arabidopsis* / metabolism
  • Arabidopsis* / microbiology
  • Botrytis* / enzymology
  • Botrytis* / pathogenicity
  • Cyclopentanes / metabolism
  • Disease Resistance
  • Fungal Proteins* / genetics
  • Fungal Proteins* / metabolism
  • Gene Expression Regulation, Plant
  • Host-Pathogen Interactions
  • Nitrogen* / metabolism
  • Plant Diseases* / microbiology
  • Plant Leaves / metabolism
  • Plant Leaves / microbiology
  • Polysaccharide-Lyases* / genetics
  • Polysaccharide-Lyases* / metabolism

Substances

  • Nitrogen
  • Polysaccharide-Lyases
  • pectin lyase
  • Fungal Proteins
  • Cyclopentanes
  • Arabidopsis Proteins

Supplementary concepts

  • Botrytis cinerea