HPV E6 and E7 mRNA Test for the Detection of High-Grade Cervical Lesions

Awoke Derbie; Melanie Maier; Bereket Amare; Eyaya Misgan; Endalkachew Nibret; Fantahun Biadglegne; Uwe G Liebert; Tsion Zewdu Minas; Muluken Agage Yenesew; Dabere Nigatu; Tesfaye B Mersha; Daniel A Enquobahrie; Yimtubezinash Woldeamanuel; Tamrat Abebe

doi:10.1001/jamanetworkopen.2024.59698

HPV E6 and E7 mRNA Test for the Detection of High-Grade Cervical Lesions

JAMA Netw Open. 2025 Feb 3;8(2):e2459698. doi: 10.1001/jamanetworkopen.2024.59698.

Authors

Awoke Derbie^{1

2}, Melanie Maier³, Bereket Amare¹, Eyaya Misgan¹, Endalkachew Nibret⁴, Fantahun Biadglegne^{1

5}, Uwe G Liebert³, Tsion Zewdu Minas^{2

6}, Muluken Agage Yenesew¹, Dabere Nigatu¹, Tesfaye B Mersha⁷, Daniel A Enquobahrie⁸, Yimtubezinash Woldeamanuel^{2

9}, Tamrat Abebe⁹

Affiliations

¹ College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
² Centre for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
³ Department of Virology, Institute of Medical Microbiology and Virology, Leipzig University Hospital, Leipzig, Germany.
⁴ Department of Biology, College of Science, Bahir Dar University, Bahir Dar, Ethiopia.
⁵ Interventional Radiology Innovation at Stanford, Department of Radiology, Stanford University School of Medicine, Palo Alto, California.
⁶ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland.
⁷ Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁸ School of Public Health, Department of Epidemiology, University of Washington, Seattle.
⁹ School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

No abstract available

Plain language summary

This cross-sectional study examines whether human papillomavirus (HPV) messenger RNA (mRNA)–based testing can identify women with high-risk abnormal cervical lesions..