From intrinsic to adaptive clusters in breast cancer

Giampaolo Bianchini; Giulia Viale; Matteo Dugo

doi:10.1016/j.ccell.2025.01.006

From intrinsic to adaptive clusters in breast cancer

Cancer Cell. 2025 Feb 10;43(2):171-173. doi: 10.1016/j.ccell.2025.01.006.

Authors

Giampaolo Bianchini¹, Giulia Viale², Matteo Dugo²

Affiliations

¹ Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milan, Italy. Electronic address: bianchini.giampaolo@hsr.it.
² Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.

PMID: 39933895
DOI: 10.1016/j.ccell.2025.01.006

Abstract

The heterogeneity of breast cancers and the availability of several therapeutic options requires prognostic and predictive tools for tailoring adjuvant treatments. In this issue of Cancer Cell, Denkert et al. analyze longitudinal gene-expression data from the Penelope-B trial and identify five adaptive clusters with independent prognostic value to established signatures.

MeSH terms

Breast Neoplasms* / drug therapy
Breast Neoplasms* / genetics
Breast Neoplasms* / pathology
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Prognosis