Modes of action of enterotoxins from Vibrio cholerae and EScherichia coli

Rev Infect Dis. 1979 Nov-Dec;1(6):918-26. doi: 10.1093/clinids/1.6.918.


Current information on the intestinal secretory mechanism and on the actions of the enterotoxins from Vibrio cholerae and Escherichia coli are reviewed. These enterotoxins, through their effects on the metabolism of cyclic nucleotides, both inhibit active absorption and stimulate active secretion of water and electrolytes in the small intestine. the enterotoxin of V. chol erae and the heat-labile enterotoxin of E. coli affect these activities by stimulating adenylate cyclase, and the heat-stable enterotoxin of E. coli does so by stimulating guanylate cyclase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Monophosphate / metabolism
  • Animals
  • Cholera / microbiology
  • Diarrhea / microbiology
  • Enterotoxins / isolation & purification
  • Enterotoxins / metabolism*
  • Escherichia coli*
  • Hot Temperature
  • Humans
  • Intestinal Secretions / microbiology
  • Rabbits
  • Vibrio cholerae*


  • Enterotoxins
  • Adenosine Monophosphate