Next generation lysosome: Brought to you by cGAS-STING

Lei Wang; Wen Zhou

doi:10.1016/j.immuni.2025.01.012

Next generation lysosome: Brought to you by cGAS-STING

Immunity. 2025 Feb 11;58(2):265-267. doi: 10.1016/j.immuni.2025.01.012. Epub 2025 Feb 11.

Authors

Lei Wang¹, Wen Zhou²

Affiliations

¹ Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
² Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address: zhouw@sustech.edu.cn.

PMID: 39938477
DOI: 10.1016/j.immuni.2025.01.012

Abstract

Renowned for driving interferon responses, the cGAS-STING pathway reveals a surprising role: lysosomal biogenesis. In this issue of Immunity, Xu et al. uncover how STING activates the transcription factor TFEB, linking innate immune sensing to enhanced pathogen clearance through lysosomal activity.

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MeSH terms

Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / immunology
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism
Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase
Humans
Immunity, Innate
Lysosomes* / immunology
Lysosomes* / metabolism
Membrane Proteins* / immunology
Membrane Proteins* / metabolism
Mice
Nucleotidyltransferases* / immunology
Nucleotidyltransferases* / metabolism
STING Protein
Signal Transduction / immunology

Substances

Nucleotidyltransferases
Membrane Proteins
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
STING1 protein, human
STING Protein
cGAS protein, human
Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase