Identification and Characterization of New Hafnia Strains from Common Carp (Cyprinus carpio), Potentially Possessing Probiotic Properties and Plastic Biodegradation Capabilities

Int J Mol Sci. 2025 Jan 28;26(3):1119. doi: 10.3390/ijms26031119.

Abstract

Finding and characterizing new bacterial strains, including probiotic strains, is a crucial task in today's world to expand the genetic data pool and identify new genes. In this study, we investigated the gut microbiota of one industrial species, Cyprinus carpio, and identified representatives of various microbial genera, including Citrobacter, Serratia, Bacillus, Enterococcus, and Kocuria. Notably, we discovered two strains of Hafnia with potentially probiotic properties. We conducted next-generation sequencing (NGS) of these strains, described their antibiotic resistance and antibacterial activity, and compared them with other representatives of the Hafnia genus. These strains, characterized by rapid growth, the presence of the ClpB heat shock protein gene, and genes associated with microplastic degradation, provide a promising basis for further research, including studies on their potential application in plastic biodegradation.

Keywords: Hafnia alvei; Hafnia paralvei; WGS; plastic biodegradation; probiotics.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Biodegradation, Environmental*
  • Carps* / microbiology
  • Gastrointestinal Microbiome* / genetics
  • High-Throughput Nucleotide Sequencing
  • Phylogeny
  • Plastics
  • Probiotics*

Substances

  • Plastics
  • Anti-Bacterial Agents