Treatment of central nervous system fungal infection with ketoconazole

Arch Intern Med. 1985 May;145(5):879-80.

Abstract

Two patients with fungal infection of the central nervous system (coccidioidal meningitis and cerebral histoplasmomas) were treated with ketoconazole for 30 months. Both responded to dosages substantially less than those described previously for similar infections. Neither patient experienced any significant adverse effects from the prolonged therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Coccidioidomycosis / diagnostic imaging
  • Coccidioidomycosis / drug therapy*
  • Drug Administration Schedule
  • Encephalitis / diagnostic imaging
  • Encephalitis / drug therapy*
  • Female
  • Histoplasmosis / diagnostic imaging
  • Histoplasmosis / drug therapy*
  • Humans
  • Ketoconazole / therapeutic use*
  • Male
  • Meningitis / diagnostic imaging
  • Meningitis / drug therapy*
  • Time Factors
  • Tomography, X-Ray Computed

Substances

  • Ketoconazole