Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice

N A Beregovoy; G K Volcho; M V Starostina

doi:10.1007/s10517-025-06323-z

Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice

Bull Exp Biol Med. 2025 Jan;178(3):291-294. doi: 10.1007/s10517-025-06323-z. Epub 2025 Feb 13.

Authors

N A Beregovoy¹, G K Volcho², M V Starostina²

Affiliations

¹ Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. n_bergg@mail.ru.
² Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.

PMID: 39948176
DOI: 10.1007/s10517-025-06323-z

Abstract

The rapid formation and high stability of addictive memory are the main causes of frequent relapse of alcohol and drug diseases, which limits the possibility of complete recovery and necessitates the search for ways to disrupt the formation or enhance the extinction of addictive memory. The present work shows that myelopeptide MP5 accelerates the extinction of morphine-induced conditioned place preference in C57BL/6 mice and supports synaptic plasticity in the hippocampus, while MP2 produced no such effects.

Keywords: addictive memory; myelopeptides; synaptic plasticity; hippocampus.

MeSH terms

Animals
Extinction, Psychological* / drug effects
Hippocampus* / drug effects
Hippocampus* / physiology
Male
Memory* / drug effects
Memory* / physiology
Mice
Mice, Inbred C57BL
Morphine / pharmacology
Neuronal Plasticity* / drug effects

Substances

Morphine