Isolated late asthmatic reaction due to nickel sulphate without antibodies to nickel

Clin Allergy. 1985 Mar;15(2):95-9. doi: 10.1111/j.1365-2222.1985.tb02261.x.


A worker with occupational exposure to nickel developed asthma a few months after starting work. Skin prick tests to nickel sulphate were negative. Inhalation challenge with nickel sulphate, at a concentration of 10 mg/ml for 30 min induced a late asthmatic reaction, starting 3 hr after the end of exposure leading to severe nocturnal attack. Tests for antibodies with nickel reactivity were negative.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Asthma / etiology*
  • Humans
  • Immunoglobulin E / analysis
  • Male
  • Nickel / adverse effects*
  • Nickel / immunology
  • Occupational Diseases / etiology*
  • Time Factors


  • Immunoglobulin E
  • nickel sulfate
  • Nickel