Minimum Requirements to Safely Establish and Sustain New Hepatic Arterial Infusion Pump Programs: An International Expert Perspective

Ryan P Merkow; Michael J Cavnar; Ana L Gleisner; Skye C Mayo; Sepideh Gholami; Paul J Karanicolas; Bas Groot Koerkamp; Marjolein Y V Homs; Louise C Connell; Andrea Cercek; Paul R Helft; Blase N Polite; Reema A Patel; Hope E Uronis; Michael D'Angelica; Michael E Lidsky

doi:10.1245/s10434-025-17009-1

Minimum Requirements to Safely Establish and Sustain New Hepatic Arterial Infusion Pump Programs: An International Expert Perspective

Ann Surg Oncol. 2025 Jun;32(6):4408-4416. doi: 10.1245/s10434-025-17009-1. Epub 2025 Feb 17.

Authors

Ryan P Merkow^#¹, Michael J Cavnar^#², Ana L Gleisner³, Skye C Mayo⁴, Sepideh Gholami⁵, Paul J Karanicolas⁶, Bas Groot Koerkamp⁷, Marjolein Y V Homs⁸, Louise C Connell⁹, Andrea Cercek⁹, Paul R Helft¹⁰, Blase N Polite¹¹, Reema A Patel¹², Hope E Uronis¹³, Michael D'Angelica^{14

15}, Michael E Lidsky¹⁶

Affiliations

¹ Department of Surgery, Division of Surgical Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
² Department of Surgery, Division of Surgical Oncology, University of Kentucky, Lexington, KY, USA.
³ Department of Surgery, University of Colorado, Aurora, CO, USA.
⁴ Department of Surgery, Division of Surgical Oncology, Oregon Health & Science University and Knight Cancer Institute, Portland, OR, USA.
⁵ Department of Surgery, Division of Surgical Oncology, Northwell Health Cancer Institute, New Hyde Park, Northwell Health, NY, USA.
⁶ Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
⁷ Department of Surgery, Cancer Institute, Erasmus MC, Rotterdam, The Netherlands.
⁸ Medical Oncology, Cancer Institute, Erasmus MC, Rotterdam, The Netherlands.
⁹ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁰ Department of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.
¹¹ Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.
¹² Department of Medicine, Division of Medical Oncology, University of Kentucky, Lexington, KY, USA.
¹³ Department of Medicine, Division of Medical Oncology, Duke University, Durham, NC, USA.
¹⁴ Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁵ Department of Surgery, Weill Cornell School of Medicine, New York, NY, USA.
¹⁶ Department of Surgery, Division of Surgical Oncology, Duke University, Durham, NC, USA. Michael.lidsky@duke.edu.

^# Contributed equally.

PMID: 39962001
DOI: 10.1245/s10434-025-17009-1

Abstract

Hepatic arterial infusion (HAI) pump chemotherapy is an effective therapy for colorectal liver metastases and intrahepatic cholangiocarcinoma. In the setting of recent reports suggesting favorable outcomes in these diseases with HAI, there has been a surge in interest in this treatment worldwide, prompting the opening of many new HAI programs. While significant technical expertise is required for pump implantation, this alone is insufficient to open a safe and sustainable HAI program, and numerous other factors must be considered prior to the first pump implantation. This expert perspective, established using an anonymous web-based survey of experienced multidisciplinary international HAI providers, details the minimum required personnel, expertise, training, and infrastructure to optimize success and sustainability of a safe and effective new HAI program.

Keywords: Expert perspective; HAI; HAIP; Hepatic artery infusion pump.

Publication types

Review

MeSH terms

Bile Duct Neoplasms* / drug therapy
Cholangiocarcinoma* / drug therapy
Colorectal Neoplasms* / drug therapy
Colorectal Neoplasms* / pathology
Hepatic Artery*
Humans
Infusions, Intra-Arterial* / instrumentation
Liver Neoplasms* / drug therapy
Liver Neoplasms* / secondary