Total fat intake and fatty acid patterns and prediabetes regression: differential effects across phenotypes in a population-based cohort

Eur J Med Res. 2025 Feb 17;30(1):110. doi: 10.1186/s40001-025-02337-5.

Abstract

Background and aim: This cohort study investigated the potential association between dietary fat intakes and returning to normal glucose regulation (NGR) in different prediabetes (Pre-DM) phenotypes.

Methods: A total of 1587 Pre-DM subjects consisting of 60.2% isolated impaired fasting glucose (iIFG), 21% isolated impaired glucose tolerance (iIGT), and 18.8% combined IFG-IGT, were recruited for baseline dietary assessment and were followed for changes in glycemic status (i.e., returned to NGR, remained Pre-DM, or progressed to diabetes) over 9 years. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for returning to NGR across categories of fat intake (< 20%, 20-30%, and > 30% of total energy intake), and tertiles of major fat patterns identified through principal component analysis (PCA).

Results: The mean age of the participants was 47.2 ± 12.9 years, and 52.2% were men. Over a median of 5.8 years of follow-up, 46.8% of Pre-DM subjects regressed to NGR. Low-fat diet (LFD) was associated with an increased chance of returning to NGR in the iIGT phenotype (HR = 1.44, 95% CI 1.05-1.98). Two major dietary fat patterns, i.e., Mixed Fat Pattern (MFP, whit a higher load of saturated fat, cholesterol, oleic, linoleic, and trans fatty acids) and ω3FP (i.e., loaded heavily on docosahexaenoic, eicosapentaenoic, and α-linolenic acids), extracted by PCA, were corresponded to 58.4% of the total variance of fat intake. In both iIFG and iIGT phenotypes, highest MFP score was inversely associated with NGR (HR = 0.71, 95% CI 0.50-0.99 and HR = 0.60, 95% CI 0.37-0.97), while the highest ω3FP score was associated with an elevated incidence of NGR in subjects with combined IFG-IGT phenotype by twofold (HR = 2.29, 95% CI 1.00-5.29).

Conclusions: Subjects with iIGT phenotype may take more advantage from adhering a LFD. Dietary fat patterns may differentially affect chance of returning to NGR across Pre-DM phenotypes.

Keywords: Dietary fat; Normoglycemia; Prediabetes phenotypes; Type 2 diabetes.

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Cohort Studies
  • Dietary Fats* / administration & dosage
  • Fatty Acids*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Prediabetic State* / blood
  • Prediabetic State* / diet therapy
  • Prediabetic State* / epidemiology

Substances

  • Dietary Fats
  • Fatty Acids
  • Blood Glucose