Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments

Yunhao Li; Fengqi Xuan; Daoyang Zhang; Mingyu Sun; Ping Zhang; Qi Zhang; Jie Zhang; Yaling Han; Zulu Wang; Ming Liang

doi:10.3389/fcvm.2025.1525762

Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments

Front Cardiovasc Med. 2025 Feb 4:12:1525762. doi: 10.3389/fcvm.2025.1525762. eCollection 2025.

Authors

Yunhao Li^#^{1

2}, Fengqi Xuan^#³, Daoyang Zhang^{1

4}, Mingyu Sun^{1

5}, Ping Zhang¹, Qi Zhang¹, Jie Zhang¹, Yaling Han^{1

5}, Zulu Wang¹, Ming Liang^{1

5}

Affiliations

¹ Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
² Graduate School of China Medical University, China Medical University, Shenyang, China.
³ Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
⁴ Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China.
⁵ National Key Laboratory of Frigid Zone Cardiovascular Diseases, Shenyang, China.

^# Contributed equally.

Abstract

Aims: The study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.

Methods: Potatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.

Results and conclusion: The key ablation parameters have varying degrees of influence on lesion depths, following the order of PW>V; V>P; PW>P; N>P. Lesion depths increased with higher values of V and P. However, when the total number of pulses reached 9,600, there was no significant increase in injury depth.

Keywords: key parameters; pre-clinical study; pulmonary vein isolation; pulsed field ablation; tomato.

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.