Direct cortisone injection in eosinophilic granuloma of bone: a preliminary report on 11 patients

J Pediatr Orthop. May-Jun 1985;5(3):339-42. doi: 10.1097/01241398-198505000-00016.


Eleven patients, between 3 and 16 years of age (average 6.5 years), with eosinophilic granuloma of bone were treated with direct injection of methylprednisolone acetate. Methylprednisolone acetate was used at the dilution of 40 mg/ml. Each single injected dose varied from 1 to 4 ml, depending on the sizes of the radiolucent defect and the soft tissue mass. One patient had four separate injections, one had three injections, five had two injections, and four had a single injection. All 11 patients healed without complications. This method of management is recommended.

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use*
  • Bone Diseases / drug therapy*
  • Child
  • Child, Preschool
  • Eosinophilic Granuloma / drug therapy*
  • Female
  • Humans
  • Male
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / analogs & derivatives*
  • Methylprednisolone / therapeutic use
  • Methylprednisolone Acetate


  • Anti-Inflammatory Agents
  • Methylprednisolone Acetate
  • Methylprednisolone