Addressing the Gaps in the Vitamin B12 Deficiency 2024 NICE Guidelines: Highlighting the Need for Better Recognition, Diagnosis, and Management of Pernicious Anaemia

Alfie Thain; Kathryn Hart; Kourosh R Ahmadi

doi:10.1038/s41430-025-01583-4

Addressing the Gaps in the Vitamin B12 Deficiency 2024 NICE Guidelines: Highlighting the Need for Better Recognition, Diagnosis, and Management of Pernicious Anaemia

Eur J Clin Nutr. 2025 Jul;79(7):607-610. doi: 10.1038/s41430-025-01583-4. Epub 2025 Feb 21.

Authors

Alfie Thain¹, Kathryn Hart², Kourosh R Ahmadi²

Affiliations

¹ School of Biosciences, Faculty of Health & Medical Sciences University of Surrey, Guildford, UK. a.thain@surrey.ac.uk.
² School of Biosciences, Faculty of Health & Medical Sciences University of Surrey, Guildford, UK.

Abstract

The 2024 NICE guidelines on vitamin B₁₂ deficiency have significant implications for the diagnosis and management of pernicious anaemia (PA), the commonest non-dietary cause of such deficiency. This perspective discusses the guidelines in relation to PA itself, suggests that clearer diagnostic protocols are required, and calls for clinician education to improve the patient journey for those with PA.

Publication types

Review

MeSH terms

Anemia, Pernicious* / diagnosis
Anemia, Pernicious* / therapy
Humans
Practice Guidelines as Topic*
United Kingdom
Vitamin B 12 / blood
Vitamin B 12 / therapeutic use
Vitamin B 12 Deficiency* / diagnosis
Vitamin B 12 Deficiency* / therapy

Substances

Vitamin B 12