Controversies in the management of serous tubal intra-epithelial carcinoma lesions of the fallopian tube

Int J Gynecol Cancer. 2025 Mar;35(3):101667. doi: 10.1016/j.ijgc.2025.101667. Epub 2025 Feb 5.

Abstract

High-grade serous carcinoma is the most lethal gynecological malignancy. Although serous tubal intra-epithelial carcinoma is increasingly recognized as a precursor to high-grade serous carcinoma, its optimal management remains controversial. This review examines the controversies in serous tubal intra-epithelial carcinoma pathogenesis, diagnosis, management, and follow-up, highlighting the need for collaboration, standardized guidelines, and further research to improve patient outcomes.

Keywords: Carcinogenesis; Ovarian Cancer; Preneoplastic Lesion.

Publication types

  • Review

MeSH terms

  • Cystadenocarcinoma, Serous / pathology
  • Cystadenocarcinoma, Serous / therapy
  • Fallopian Tube Neoplasms* / pathology
  • Fallopian Tube Neoplasms* / therapy
  • Female
  • Humans