Charting a novel path towards Ebola virus disease preparedness: Considerations for preventive vaccination

PLoS Med. 2025 Feb 24;22(2):e1004543. doi: 10.1371/journal.pmed.1004543. eCollection 2025 Feb.

Abstract

In June 2024, Gavi, the Vaccine Alliance, launched a preventive vaccination program against Ebola virus disease (EVD). This marks a historic shift in the management of EVD, allowing at-risk countries across sub-Saharan Africa to request support in implementing preventive vaccination campaigns. This perspective piece shares considerations that can inform how countries approach preventive EVD vaccination and potential unintended consequences. It also provides insights into strategies for vaccines against other epidemic-prone pathogens.

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Ebola Vaccines* / administration & dosage
  • Ebolavirus* / immunology
  • Hemorrhagic Fever, Ebola* / epidemiology
  • Hemorrhagic Fever, Ebola* / prevention & control
  • Humans
  • Immunization Programs*
  • Vaccination* / methods

Substances

  • Ebola Vaccines