Bioanalytical Assays for Oligonucleotide Therapeutics: Adding Antibody-Based Immunoassays to the Toolbox as an Orthogonal Approach to LC-MS/MS and Ligand Binding Assays

Nucleic Acid Ther. 2025 Feb;35(1):6-15. doi: 10.1089/nat.2024.0065.

Authors

David P Chimento¹, Amy L Anderson¹, Inês Fial², Carl A Ascoli¹

Affiliations

¹ Rockland Immunochemicals Inc., Limerick, Pennsylvania, USA.
² Medical Research Council Functional Genomics Unit, Nucleic Acid Therapy Accelerator (NATA), Research Complex at Harwell, Oxford, United Kingdom.

PMID: 39993214
DOI: 10.1089/nat.2024.0065

No abstract available

Keywords: analytical assays; antibody-based assays; localization; oligonucleotide therapeutics; quantification.