The effect of anabolic steroids on lean body mass: the dose response curve

Metabolism. 1985 Jun;34(6):571-3. doi: 10.1016/0026-0495(85)90196-9.


Data from human subjects given various amounts of anabolic steroids show that the resultant increment in lean body mass (LBM) has the features of a typical dose response curve. Low doses produce a very modest effect, while large doses result in a progressive augmentation of the LBM. Endogenous testosterone production during male adolescence is accompanied by a sex differential in LBM that is comparable to the LBM increment generated by exogenous steroids given to adults.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anabolic Agents / administration & dosage
  • Anabolic Agents / pharmacology*
  • Body Weight / drug effects*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Nitrogen / metabolism
  • Oxandrolone / pharmacology
  • Testosterone / analogs & derivatives
  • Testosterone / pharmacology
  • Weight Lifting


  • Anabolic Agents
  • Testosterone
  • Oxandrolone
  • testosterone enanthate
  • testosterone 17 beta-cypionate
  • Nitrogen