Effect of Chloroquine on Cultured Fibroblasts: Release of Lysosomal Hydrolases and Inhibition of Their Uptake

Biochem Biophys Res Commun. 1975 Oct 27;66(4):1338-43. doi: 10.1016/0006-291x(75)90506-9.

MeSH terms

  • Biological Transport
  • Cells, Cultured
  • Cerebroside-Sulfatase / metabolism*
  • Chloroquine / pharmacology*
  • Dextrans / metabolism
  • Fibroblasts / enzymology
  • Fibroblasts / metabolism
  • Glucuronidase / metabolism*
  • Humans
  • Leukodystrophy, Metachromatic / enzymology
  • Lysosomes / drug effects
  • Lysosomes / enzymology*
  • Pinocytosis / drug effects
  • Skin / enzymology
  • Sulfatases / metabolism*

Substances

  • Dextrans
  • Chloroquine
  • Sulfatases
  • Cerebroside-Sulfatase
  • Glucuronidase