Orthophenylphenol mutagenicity in a human cell strain

Mutat Res. Apr-May 1985;156(1-2):123-7. doi: 10.1016/0165-1218(85)90015-1.

Abstract

Orthophenylphenol (OPP), a widely used fungicide, induced ouabain-resistant (OuaR) mutants in a ultraviolet (UV)-sensitive human RSa cell strain and the frequencies increased in a dose-related fashion. OPP was a more potent mutagen than UV at doses related to equal survival. These results suggest that OPP has a mutagenic activity and that further experiments on this chemical are warranted.

MeSH terms

  • Biphenyl Compounds / toxicity*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Drug Resistance
  • Humans
  • Mutagenicity Tests
  • Mutation / drug effects*
  • Mutation / radiation effects
  • Ouabain / pharmacology

Substances

  • Biphenyl Compounds
  • Ouabain
  • 2-phenylphenol