Quaternary structure of the acetylcholine receptor

Nature. 1985 Jun 6-12;315(6019):474-7. doi: 10.1038/315474a0.


The five membrane-spanning subunits of the acetylcholine receptor have been resolved in electron microscope images and are shown to lie at pentagonally symmetrical positions around the channel over a large fraction of their length. The channel consists of a wide synaptic portion and a narrow portion extending through the membrane into the interior of the cell.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Crystallography
  • Macromolecular Substances
  • Membrane Proteins
  • Microscopy, Electron
  • Protein Conformation
  • Receptors, Cholinergic*
  • Torpedo


  • Macromolecular Substances
  • Membrane Proteins
  • Receptors, Cholinergic