Renal magnesium and phosphate wastage in a patient with hypercalciuria and nephrocalcinosis: effect of oral phosphorus and magnesium supplements

Nephron. 1985;40(1):83-7. doi: 10.1159/000183434.


We report a 29-year-old man with a mild decrease in glomerular filtration, nephrocalcinosis, hypercalciuria and a renal magnesium leak. He had other features of 'congenital magnesium-losing kidney', such as arthritis and hyperuricemia, short stature and recurrent urinary tract infections, but had no radiological chondrocalcinosis. In addition, pallidal calcification was found. The patient also had a renal phosphate leak. Phosphorus supplements resulted in a decrease in urinary calcium excretion, indicating that hypercalciuria was at least partially a consequence of phosphorus depletion. Plasma and urine magnesium were not affected by phosphorus supplements. Addition of magnesium supplements resulted in a transient and modest decrease in urinary calcium excretion, with no modification in plasma magnesium.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Calcium / urine
  • Humans
  • Hypophosphatemia, Familial / complications
  • Hypophosphatemia, Familial / drug therapy
  • Magnesium / administration & dosage
  • Magnesium / blood
  • Magnesium / therapeutic use*
  • Male
  • Nephrocalcinosis / complications*
  • Nephrocalcinosis / drug therapy
  • Phosphorus / administration & dosage
  • Phosphorus / therapeutic use*


  • Phosphorus
  • Magnesium
  • Calcium