Epidermodysplasia verruciformis (EV) is an uncommon disease that is inherited autosomal recessively. It has a heightened vulnerability to human papillomavirus (HPV) infection, which manifests as hyperpigmented or hypopigmented macular lesions, lesions resembling pityriasis versicolor (PV) and planar warts, and an increased risk of progressing to skin cancer, especially in sun-exposed areas. We report three cases of EV with varying presentations. One patient, a long-standing case of EV, developed squamous cell carcinoma (SCC) in the vulva and inguinal region. Another patient had a rare association with palmar pits, while the third patient presented with classical EV. All our patients were prescribed oral retinoids and advised to practice stringent photoprotection after histopathology confirmed evidence of EV.
Keywords: edv; epidermodysplasia verruciformis; ev; hpv; lewandowski-lutz dysplasia; squamous cell carcinoma; vulval carcinoma.
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