Multifocal recurrent periostitis responsive to colchicine

Scand J Rheumatol. 1985;14(1):8-14. doi: 10.3109/03009748509102009.


A brother and sister with multifocal recurrent periostitis are presented. Their disease started at an early age and manifested itself as an episodic migrating arthropathy. At roentgenography, reversible solid periosteal reactions were visible along large tubular bones. Scintigraphic and histological investigations revealed a sterile osteitis and thickened periosteum, but there was no indication of a viral infection. The girl experienced spontaneous amelioration after puberty; the boy improved markedly on colchicine.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use
  • Child, Preschool
  • Colchicine / therapeutic use*
  • Female
  • Growth Disorders / chemically induced
  • Humans
  • Infant
  • Male
  • Periostitis / drug therapy*
  • Periostitis / genetics
  • Prednisone / therapeutic use
  • Tetracycline / therapeutic use
  • Tibia / pathology


  • Adrenal Cortex Hormones
  • Tetracycline
  • Colchicine
  • Prednisone