Aims: This study aimed to evaluate the potential of Eryngium maritimum L. (EM) callus media filtrate (ECMF) for enhanced skin delivery through multilayered liposomes (MLs).
Materials & methods: ECMF was applied to human skin cells to assess its antioxidant, anti-inflammatory, and skin barrier-enhancing properties. ECMF was encapsulated in MLs to enhance delivery efficiency, creating a formulation called Cellbiome. Clinical trials involving human participants were conducted to compare its effects with traditional formulations, assessing parameters such as skin density, hydration, elasticity, and wrinkle reduction.
Results: Cellbiome significantly improved skin density and moisturization, outperforming conventional formulations. ML encapsulation facilitated deeper penetration of active ingredients beyond the stratum corneum, leading to synchronized improvements in multiple skin parameters, including elasticity, wrinkle reduction, and overall skin health. Transcriptomic and metabolomic analyses further confirmed ECMF's bioactivity and its role in skin improvement.
Conclusions: ML-based formulations, such as Cellbiome, offer superior efficacy in skincare applications compared to conventional methods. This study underscores the importance of advanced delivery technologies in cosmetics and highlights the need for further research to optimize the benefits of natural extracts like EM for human skin, potentially advancing dermatological and cosmeceutical applications.
Keywords: Eryngium maritimum L.; callus extract; liposome; moisturization; skin; skin barrier.
Healthy skin plays a crucial role in protecting the body, but factors like aging, pollution, and stress can weaken the skin barrier, leading to dryness, wrinkles, and irritation. In this study, we explored the potential benefits of Eryngium maritimum (EM) callus media filtrate (ECMF) for improving skin health. To enhance its absorption into the skin, we encapsulated the extract in protective vesicles called multilayered liposomes (MLs) to create a new formulation, Cellbiome. We tested Cellbiome in in vitro studies and human clinical trials. The results showed that Cellbiome significantly improved skin hydration, density, and elasticity, making the skin appear healthier and reducing wrinkles. The ML technology allowed the active ingredients to penetrate deeper into the skin compared to traditional skincare products, leading to better overall results. Our findings highlight the potential of advanced delivery systems like MLs to improve the effectiveness of natural skincare ingredients. Cellbiome may provide a more effective solution for skin hydration, anti-aging, and overall skin health. Further research could help optimize these benefits and expand their use in dermatology and cosmetics.