Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment

Lunguo Xia; Chenchen Zhou; Peng Mei; Zuolin Jin; Hong He; Lin Wang; Yuxing Bai; Lili Chen; Weiran Li; Jun Wang; Min Hu; Jinlin Song; Yang Cao; Yuehua Liu; Benxiang Hou; Xi Wei; Lina Niu; Haixia Lu; Wensheng Ma; Peijun Wang; Guirong Zhang; Jie Guo; Zhihua Li; Haiyan Lu; Liling Ren; Linyu Xu; Xiuping Wu; Yanqin Lu; Jiangtian Hu; Lin Yue; Xu Zhang; Bing Fang

doi:10.1038/s41368-024-00335-7

Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment

Int J Oral Sci. 2025 Mar 1;17(1):13. doi: 10.1038/s41368-024-00335-7.

Authors

Lunguo Xia^#¹, Chenchen Zhou^#², Peng Mei^#¹, Zuolin Jin³, Hong He⁴, Lin Wang⁵, Yuxing Bai⁶, Lili Chen⁷, Weiran Li⁸, Jun Wang⁹, Min Hu¹⁰, Jinlin Song¹¹, Yang Cao¹², Yuehua Liu¹³, Benxiang Hou¹⁴, Xi Wei¹⁵, Lina Niu¹⁶, Haixia Lu¹⁷, Wensheng Ma¹⁸, Peijun Wang¹⁹, Guirong Zhang²⁰, Jie Guo²¹, Zhihua Li²², Haiyan Lu²³, Liling Ren²⁴, Linyu Xu²⁵, Xiuping Wu²⁶, Yanqin Lu²⁷, Jiangtian Hu²⁸, Lin Yue²⁹, Xu Zhang³⁰, Bing Fang³¹

Affiliations

¹ Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
² State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
³ State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, Air Force Medical University, Xi'an, China.
⁴ Department of Orthodontics, Hubei-MOST KLOS and KLOBM, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
⁵ Department of Orthodontics, Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China.
⁶ Department of Orthodontics, Capital Medical University School of Stomatology, Beijing, China.
⁷ Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.
⁸ Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
⁹ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
¹⁰ Department of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, China.
¹¹ Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
¹² Department of Orthodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
¹³ Department of Orthodontics, Shanghai Stomatological Hospital, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
¹⁴ Center for Microscope Enhanced Dentistry, Capital Medical University School of Stomatology, Beijing, China.
¹⁵ Department of Operative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
¹⁶ Department of Prosthodontics, School of Stomatology, Air Force Medical University, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Xi'an, China.
¹⁷ Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
¹⁸ Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China.
¹⁹ Department of Orthodontics, School of Stomatology, Harbin Medical University, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
²⁰ Department of Orthodontics, Shenyang Stomatological Hospital, Shenyang, China.
²¹ Department of Orthodontics, School and Hospital of Stomatology, Shandong University, Jinan, China.
²² Department of Orthodontics, Affiliated Stomatological Hospital of Nanchang University, Jiangxi Provincial Key Laboratory of Oral Biomedicine, Nanchang, China.
²³ Department of Orthodontics, School and Hospital of Stomatology, Hebei Medical University, Hebei Provincial Key Laboratory of Stomatology, Hebei Provincial Clinical Research Center for Oral Diseases, Shijiazhuang, China.
²⁴ School of Stomatology, Lanzhou University, Lanzhou, China.
²⁵ Department of Orthodontics, Fujian Key Laboratory of Oral Diseases, Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
²⁶ Department of Orthodontics, School and Hospital of Stomatology, Shanxi Medical University, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, China.
²⁷ Department of Orthodontics, Xiangya Stomatology Hospital, Central South University, Changsha, China.
²⁸ Department of Orthodontics, Affiliated Stomatological Hospital of Kunming Medical University, Kunming, China.
²⁹ Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Beijing, China. kqlinyue@bjmu.edu.cn.
³⁰ School and Hospital of Stomatology, Institute of Stomatology, Tianjin Medical University, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin, China. zhangxu@tmu.edu.cn.
³¹ Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China. fangbing@sjtu.edu.cn.

^# Contributed equally.

Abstract

Enamel demineralization, the formation of white spot lesions, is a common issue in clinical orthodontic treatment. The appearance of white spot lesions not only affects the texture and health of dental hard tissues but also impacts the health and aesthetics of teeth after orthodontic treatment. The prevention, diagnosis, and treatment of white spot lesions that occur throughout the orthodontic treatment process involve multiple dental specialties. This expert consensus will focus on providing guiding opinions on the management and prevention of white spot lesions during orthodontic treatment, advocating for proactive prevention, early detection, timely treatment, scientific follow-up, and multidisciplinary management of white spot lesions throughout the orthodontic process, thereby maintaining the dental health of patients during orthodontic treatment.

Publication types

Consensus Statement
Research Support, Non-U.S. Gov't

MeSH terms

Dental Caries* / etiology
Dental Caries* / prevention & control
Dental Caries* / therapy
Dental Enamel* / pathology
Humans
Tooth Demineralization* / etiology
Tooth Demineralization* / prevention & control
Tooth Demineralization* / therapy
Tooth Remineralization

Abstract

Publication types

MeSH terms

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