Increased Epstein-Barr virus reactivation but similar incidence of post-transplant lymphoproliferative disorders due to pre-emptive rituximab therapy following allogeneic hematopoietic stem cell transplantation in the letermovir era for cytomegalovirus prophylaxis

Sisi Zhen; Li Liu; Xiaoyu Zhang; Jieru Wang; Jiali Sun; Chen Liang; Wenbin Cao; Jialin Wei; Weihua Zhai; Xin Chen; Qiaoling Ma; Rongli Zhang; Donglin Yang; Yi He; Aiming Pang; Mingzhe Han; Erlie Jiang; Sizhou Feng

doi:10.1038/s41409-025-02542-0

Increased Epstein-Barr virus reactivation but similar incidence of post-transplant lymphoproliferative disorders due to pre-emptive rituximab therapy following allogeneic hematopoietic stem cell transplantation in the letermovir era for cytomegalovirus prophylaxis

Bone Marrow Transplant. 2025 May;60(5):721-724. doi: 10.1038/s41409-025-02542-0. Epub 2025 Mar 3.

Authors

Sisi Zhen^#^{1

2}, Li Liu^#^{1

2}, Xiaoyu Zhang^#^{1

2}, Jieru Wang^{1

2}, Jiali Sun^{1

2}, Chen Liang^{1

2}, Wenbin Cao^{1

2}, Jialin Wei^{1

2}, Weihua Zhai^{1

2}, Xin Chen^{1

2}, Qiaoling Ma^{1

2}, Rongli Zhang^{1

2}, Donglin Yang^{1

2}, Yi He^{1

2}, Aiming Pang^{1

2}, Mingzhe Han^{1

2}, Erlie Jiang^{3

4}, Sizhou Feng^{5

6}

Affiliations

¹ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China.
² Tianjin Institutes of Health Science, Tianjin, PR China.
³ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China. doctor_eljiang@163.com.
⁴ Tianjin Institutes of Health Science, Tianjin, PR China. doctor_eljiang@163.com.
⁵ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China. szfeng@ihcams.ac.cn.
⁶ Tianjin Institutes of Health Science, Tianjin, PR China. szfeng@ihcams.ac.cn.

^# Contributed equally.

PMID: 40033131
DOI: 10.1038/s41409-025-02542-0

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