Objectives: Salivary gland-type intraductal carcinoma (IC) is a rare type of low-grade salivary gland neoplasm. Given that the clinical and imaging features of primary lung IC are nonspecific, the diagnosis requires pathologic analysis.
Methods: We report a 63-year-old woman with primary low-grade salivary gland-type IC of the lung, characterized by an origin from the bronchus submucosa, an intraductal or intracavity growth of ductal epithelium, an absence of interstitial infiltration, and harboring an RET::CCDC6 fusion.
Results: Through case presentation and a literature review, we discuss the differential diagnosis and clinical management of salivary gland-type IC of the lung.
Conclusions: Molecular testing is not necessary for histologic subtyping but can aid in the differential diagnosis of IC.
Keywords: CCDC6::RET fusion; diagnosis; lung neoplasms; pathology; primary lung intraductal carcinoma.
© The Author(s) 2025. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.