Toward AI-Driven Precision Measurement of Cognition, Behavior, and Psychological Function in Aging and Alzheimer's Disease and Alzheimer's Disease-Related Dementias

Luke E Stoeckel; Dinesh John; Matthew Sutterer

doi:10.1093/geronb/gbaf045

Toward AI-Driven Precision Measurement of Cognition, Behavior, and Psychological Function in Aging and Alzheimer's Disease and Alzheimer's Disease-Related Dementias

J Gerontol B Psychol Sci Soc Sci. 2025 Jun 10;80(7):gbaf045. doi: 10.1093/geronb/gbaf045.

Authors

Luke E Stoeckel¹, Dinesh John¹, Matthew Sutterer^{1

2}

Affiliations

¹ Division of Behavioral and Social Research, National Institute on Aging, Bethesda, Maryland, USA.
² Division of Neuroscience, National Institute on Aging, Bethesda, Maryland, USA.

PMID: 40036675
DOI: 10.1093/geronb/gbaf045

Abstract

The National Institute on Aging (NIA) is at the forefront of leveraging advances in artificial intelligence (AI) to better understanding of aging and the diagnosis and treatment of Alzheimer's Disease (AD) and Alzheimer's disease-related dementias (ADRD). Recent NIA-supported projects have highlighted the transformative potential of AI, digital health, and computational approaches in improving the modeling, detection, and monitoring of changes in healthy aging and AD/ADRD. This perspective is forward looking, emphasizing key areas and efforts in AI-driven precision measurement in cognition, behavior, and psychological function.

Published by Oxford University Press on behalf of the Gerontological Society of America 2025.

MeSH terms

Aged
Aging* / psychology
Alzheimer Disease* / diagnosis
Alzheimer Disease* / psychology
Artificial Intelligence*
Cognition*
Dementia* / diagnosis
Dementia* / psychology
Humans
National Institute on Aging (U.S.)
United States