Abnormal breathing patterns during sleep in diabetes

Ann Neurol. 1985 Apr;17(4):391-5. doi: 10.1002/ana.410170415.


Nineteen diabetic patients, 12 type I (insulin-dependent) and 7 type II (late-onset, non-insulin-dependent), underwent nocturnal polygraphic monitoring after a daytime medical evaluation that included tests of vagal responses and, in 6 patients, pulmonary function and hypercapnic and hypoxic responses. Five lean type I patients had abnormal sleep-related breathing patterns with central or obstructive sleep apnea and brief breathing irregularities during stages 3 to 4 non-rapid-eye-movement sleep, compared with only 1 overweight type II diabetic with moderate obstructive sleep apnea. There was no correlation between daytime ventilatory study findings and abnormal breathing patterns during sleep, but there was a clear relationship between neuropathy and sleep-related breathing abnormalities in type I insulin-dependent diabetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Respiratory Function Tests
  • Sleep Apnea Syndromes / complications*
  • Sleep, REM
  • Time Factors