Mpox in a Patient With a Signal Transducer and Activator of Transcription 1 Gain-of-Function Mutation

Abstract

We report a case of mpox in a patient with a signal transducer and activator of transcription 1 gain-of-function mutation. Despite initial improvement with intravenous immune globulin and tecovirimat, severe symptoms developed and the patient died. This underscores the need for immune system optimization and effective virucidal treatments for mpox.