When does rheumatoid disease start?

Arthritis Rheum. 1985 May;28(5):485-9. doi: 10.1002/art.1780280503.


Stored serum specimens collected in connection with a community-oriented epidemiologic study were available from 30 subjects who later developed seropositive rheumatoid arthritis. In 9 of these pre-rheumatoid specimens, the Rose-Waaler test result was positive, and in 16, the latex fixation test was positive. Two-thirds of the samples were positive when the interval between taking the blood specimen and onset of the disease was less than 4 years, and one-third were positive when the interval was greater than or equal to 4 years. The occurrence of rheumatoid factor preceded the onset of clinical disease more often in males than in females.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / diagnosis*
  • Female
  • Humans
  • Latex Fixation Tests
  • Male
  • Middle Aged
  • Prognosis
  • Rheumatoid Factor / immunology*
  • Time Factors


  • Rheumatoid Factor