Insights into palmitoylation-mediated regulation of inflammasomes

Qiwei Jiang; Lang Bu; Jianping Guo

doi:10.1016/j.it.2025.02.008

Insights into palmitoylation-mediated regulation of inflammasomes

Trends Immunol. 2025 Apr;46(4):266-269. doi: 10.1016/j.it.2025.02.008. Epub 2025 Mar 5.

Authors

Qiwei Jiang¹, Lang Bu¹, Jianping Guo²

Affiliations

¹ Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
² Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510275, China. Electronic address: guojp6@mail.sysu.edu.cn.

PMID: 40050162
DOI: 10.1016/j.it.2025.02.008

Abstract

The mammalian inflammasome is crucial for responding to environmental/intrinsic stress, and its regulation remains a significant focus in immune-mediated inflammatory diseases and antitumor immunity. Recent studies highlight a close link between palmitoylation and inflammasome regulation. However, this type of regulation remains elusive but may harbor potential for combating inflammation-driven disorders.

Keywords: NLRP3; gasdermin D; inflammasome; mitochondrial antiviral signaling protein; palmitoylation.

Publication types

Review

MeSH terms

Animals
Humans
Inflammasomes* / immunology
Inflammasomes* / metabolism
Inflammation / immunology
Inflammation / metabolism
Lipoylation*

Substances

Inflammasomes