Description of the Novel Allele HLA-B*18:01:56 With Two Synonymous Substitutions

HLA. 2025 Mar;105(3):e70098. doi: 10.1111/tan.70098.

Abstract

HLA-B*18:01:56 showed two synonymous nucleotide differences compared to the HLA-B*18:01:01:01 allele in codons 224 and 225.

Keywords: NGS HLA typing novel; novel HLA‐B allele; HLA‐B*18:01:56.

MeSH terms

  • Alleles*
  • Amino Acid Substitution
  • Base Sequence
  • Codon / chemistry
  • Exons*
  • HLA-B18 Antigen* / genetics
  • HLA-B18 Antigen* / immunology
  • Histocompatibility Testing
  • Humans
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Silent Mutation*

Substances

  • Codon
  • HLA-B18 Antigen