Testing the statistical certainty of a response to increasing doses of a drug

Biometrics. 1985 Mar;41(1):295-301.


Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.

MeSH terms

  • Animals
  • Biometry
  • Dogs
  • Dose-Response Relationship, Drug*
  • Regression Analysis
  • Serum Albumin / analysis
  • Toxicology*


  • Serum Albumin