The skin, as the largest organ in the human body, serves as the primary physical barrier and plays a crucial role in the immune defense process. Immune-related skin diseases encompass a spectrum of complex dermatological conditions characterized by aberrant immune responses, including the production of autoantibodies and dysregulation of inflammatory mediators. Growing evidence suggest a heightened prevalence of comorbid neuropsychiatric disorders among patients with immune-related skin diseases, indicative of potential shared pathogenesis. In recent years, the brain connectome, delineating the intricate network of neural connections, has gained prominence in elucidating various neurological and psychiatric conditions. Researchers have begun to investigate whether alterations in brain connectivity occur in patients with immune-related skin diseases, thereby exploring the connectome perspective in understanding the pathogenesis of these diseases. This review aims to synthesize and analyze recent neuroimaging studies about immune-related skin diseases, including systemic lupus erythematosus, psoriasis, chronic spontaneous urticaria, and atopic dermatitis. We mainly discussed the connectome studies related to these diseases and summarized the underlying mechanisms associated with their clinical manifestations, progression, and treatment. Then from our perspectives, we believe that interdisciplinary collaborations encompassing fields such as neurology, psychiatry, dermatology, and neuroimaging will be instrumental in advancing our understanding of immune-related skin diseases. Furthermore, multi-omics approaches will enable a comprehensive exploration of the molecular mechanisms underlying these neural changes, facilitating the identification of novel diagnostic biomarkers and therapeutic targets.
Keywords: Connectome; Immune-related skin diseases; MRI; Neuroimaging.
© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.