Although the quality movement in healthcare in the United States has been maturing for the last several decades, neurology remains a frontier of work related to learning healthcare systems (LHS) and the science of improvement. This review describes the use of LHS models in neurology and the use of Improvement Science to advance position system changes and improve care. LHSs are broadly understandable, widely supported, and have a developing yet proven track record. However, there are distinct challenges at multiple levels in successful implementation, as well as nuances related to variability in practice patterns and institutions. This review outlines these hurdles and approaches to addressing them. There are examples of effective work currently being conducted in this emerging field, with an emphasis on two subspecialties that have been the primary early adopters of these models and methodology within neurology: stroke and epilepsy. As LHS models take shape in neurology subspecialties, there will be an ongoing need for collaboration and iterative change to support continuous improvement in systems of care and improve outcomes for patients with neurologic disease.
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