1 Department of Medicine and Surgery, University of Enna "Kore", 94100, Enna, Italy.
2 Mediterranean Foundation "GB Morgagni", 95125, Catania, Italy. sergio.castorina@unict.it.
3 Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123, Catania, Italy. sergio.castorina@unict.it.