Neither dietary ethanol nor beer augments experimental colon carcinogenesis in rats

Dis Colon Rectum. 1985 Jun;28(6):460-2. doi: 10.1007/BF02560238.


There is an epidemiologic association between beer consumption and rectal cancer. Beer and ethanol were tested in the rat-dimethylhydrazine (DMH) experimental carcinogenesis model in order to verify this observation. Ethanol was found not to affect the number of colonic tumors induced by DMH (86 vs. 77 controls, P = 0.764). In rats fed beer and treated with DMH, there was a decrease in gastrointestinal tumor induction (P = 0.043). This instance then becomes one of many in which conclusions drawn from epidemiologic studies have been contradicted when subjected to analysis in an experimental colon carcinogenesis model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1,2-Dimethylhydrazine
  • Animals
  • Beer / toxicity*
  • Cocarcinogenesis*
  • Colonic Neoplasms / chemically induced*
  • Diet
  • Dimethylhydrazines
  • Ethanol / toxicity*
  • Male
  • Rats
  • Rats, Inbred Strains


  • Dimethylhydrazines
  • Ethanol
  • 1,2-Dimethylhydrazine