Sex Differences in Peripheral Vascular Disease: A Scientific Statement From the American Heart Association

Circulation. 2025 Apr 8;151(14):e877-e904. doi: 10.1161/CIR.0000000000001310. Epub 2025 Mar 11.

Abstract

Sex differences in the risk factors, diagnosis, treatment, and outcomes of patients with cardiovascular disease have been well described; however, the bulk of the literature has focused on heart disease in women. Data on sex differences in peripheral vascular disease are ill defined, and there is a need to report and understand those sex-related differences to mitigate adverse outcomes related to those disparities. Although peripheral vascular disease is a highly diverse group of disorders affecting the arteries, veins, and lymphatics, this scientific statement focuses on disorders affecting the peripheral arteries to include the aorta and its branch vessels. The purpose of this scientific statement is to report the current status of sex-based differences and disparities in peripheral vascular disease and to provide research priorities to achieve health equity for women with peripheral vascular disease.

Keywords: AHA Scientific Statements; aneurysm; carotid artery diseases; peripheral arterial disease; peripheral vascular diseases; sex characteristics; vasculitis; women.

Publication types

  • Review

MeSH terms

  • American Heart Association
  • Female
  • Health Status Disparities
  • Humans
  • Male
  • Peripheral Vascular Diseases* / diagnosis
  • Peripheral Vascular Diseases* / epidemiology
  • Peripheral Vascular Diseases* / therapy
  • Risk Factors
  • Sex Characteristics*
  • Sex Factors
  • United States / epidemiology