Meiosis: When centromeres choose compromise over conflict

Shreyas Sridhar; Tatsuo Fukagawa

doi:10.1016/j.cub.2025.01.059

Meiosis: When centromeres choose compromise over conflict

Curr Biol. 2025 Mar 10;35(5):R196-R198. doi: 10.1016/j.cub.2025.01.059.

Authors

Shreyas Sridhar¹, Tatsuo Fukagawa²

Affiliations

¹ Graduate School of Frontier Biosciences, The University of Osaka, Suita, Osaka 565-0871, Japan. Electronic address: sridhar.shreyas.fbs@osaka-u.ac.jp.
² Graduate School of Frontier Biosciences, The University of Osaka, Suita, Osaka 565-0871, Japan. Electronic address: fukagawa.tatsuo.fbs@osaka-u.ac.jp.

PMID: 40068619
DOI: 10.1016/j.cub.2025.01.059

Abstract

Centromeres are essential for accurate chromosome segregation, yet their DNA and proteins evolve rapidly. A new study reveals that mouse CENP-T evolved reduced centromere binding, not to counter selfish DNA, but to stabilize kinetochore dynamics and ensure successful oogenesis, reshaping ideas about centromere adaptation.

MeSH terms

Animals
Centromere* / metabolism
Centromere* / physiology
Chromosomal Proteins, Non-Histone* / genetics
Chromosomal Proteins, Non-Histone* / metabolism
Chromosome Segregation
Kinetochores / metabolism
Meiosis* / physiology
Mice
Oogenesis

Substances

Chromosomal Proteins, Non-Histone