Evaluation of omadacycline in vitro activity against Corynebacterium species

Antimicrob Agents Chemother. 2025 Apr 2;69(4):e0186424. doi: 10.1128/aac.01864-24. Epub 2025 Mar 12.

Abstract

Corynebacterium spp. are gram-positive bacteria increasingly recognized as pathogens. This study evaluates the MICs of omadacycline, a tetracycline, against 40 clinical Corynebacterium isolates using two methodologies: broth microdilution (BMD) and Liofilchem omadacycline MIC Test Strip (MTS). By BMD, the MIC50, MIC90, and MIC range were 0.5 µg/mL, 1 µg/mL, and 0.12-2.0 µg/mL, respectively. Comparing BMD to MTS, essential agreement (EA, within ±1 doubling dilution of the reference BMD MIC) was 87.5% (95% CI: 73.0%-95.4%).

Keywords: Corynebacterium; omadacycline; susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Corynebacterium* / drug effects
  • Corynebacterium* / isolation & purification
  • Humans
  • Microbial Sensitivity Tests
  • Tetracyclines* / pharmacology

Substances

  • Anti-Bacterial Agents
  • Tetracyclines
  • omadacycline