Direct effect of insulin on secretion of insulin, glucagon, gastric inhibitory polypeptide, and gastrin during maintenance of normoglycemia

J Clin Endocrinol Metab. 1978 Sep;47(3):488-93. doi: 10.1210/jcem-47-3-488.


The direct effect of insulin on the secretion of insulin (as measured by C-peptide), glucagon, gastric inhibitory polypeptide, and gastrin was studied in normal subjects by infusing insulin while the plasma level of glucose was maintained in the normal fasting range (euglycemic clamp). Insulin-induced hypoglycemia resulted in increases in circulating glucagon and gastric inhibitory polypeptide, a decrease in C-peptide, and no change in gastrin levels. In contrast, during the euglycemic clamp, insulin was found to behave a direct suppressive effect on the secretion of glucagon, C-peptide, and gastrin, but no effect on levels of gastric inhibitory polypeptide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Glucose / metabolism*
  • Feedback
  • Gastric Inhibitory Polypeptide / metabolism*
  • Gastrins / metabolism*
  • Gastrointestinal Hormones / metabolism*
  • Glucagon / metabolism*
  • Humans
  • Insulin / metabolism*
  • Insulin Secretion
  • Kinetics


  • Blood Glucose
  • Gastrins
  • Gastrointestinal Hormones
  • Insulin
  • Gastric Inhibitory Polypeptide
  • Glucagon