During May-December 2024, we detected Oropouche virus (OROV) in 13.9% (263/1,890) of febrile patients in Ceará state, Brazil. Genomic sequencing revealed those cases were caused by a novel OROV reassortant previously identified in the Amazon region. Our data show the introduction and establishment of OROV transmission in Ceará, northeastern Brazil.
Keywords: Brazil; Oropouche fever; Oropouche virus; Peribunyaviridae; arbovirus; neglected tropical diseases; vector-borne infections; vector-borne orthobunyavirus; viruses.