The inseparable relationship between constipation and blood pressure

Tatsuhiko Kume; Masaki Mogi

doi:10.1038/s41440-025-02185-0

The inseparable relationship between constipation and blood pressure

Hypertens Res. 2025 May;48(5):1687-1689. doi: 10.1038/s41440-025-02185-0. Epub 2025 Mar 14.

Authors

Tatsuhiko Kume^{1

2}, Masaki Mogi³

Affiliations

¹ Department of Pharmacology, Ehime University Graduate School of Medicine, Tohon, Japan.
² Department of Gastrointestinal Surgery and Surgical Oncology, Ehime University Graduate School of Medicine, Tohon, Japan.
³ Department of Pharmacology, Ehime University Graduate School of Medicine, Tohon, Japan. mogi.masaki.me@ehime-u.ac.jp.

PMID: 40087466
DOI: 10.1038/s41440-025-02185-0

Abstract

Schematic presentation of the possible mechanisms in the association between hypertension and constipation including sympathetic overactivity, antihypertensives, and gut microbiota.

Keywords: autonomic dysregulation; cardiovascular risk; constipation; gut microbiota.

Publication types

Editorial

MeSH terms

Antihypertensive Agents / therapeutic use
Blood Pressure* / physiology
Constipation* / complications
Constipation* / physiopathology
Gastrointestinal Microbiome / physiology
Humans
Hypertension* / complications
Hypertension* / drug therapy
Hypertension* / physiopathology
Sympathetic Nervous System / physiopathology

Substances

Antihypertensive Agents