Neural Patterns of Social Pain in the Brain-Wide Representations Across Social Contexts

Abstract

Empathy can be elicited by physiological pain, as well as in social contexts. Although physiological and different social contexts induce a strong subjective experience of empathy, the general and context-specific neural representations remain elusive. Here, it is combined fMRI with multivariate pattern analysis (MVPA) to establish neurofunctional models for social pain triggered by observing social exclusion and separation naturistic stimuli. The findings revealed that both social contexts engaged the empathy and social function networks. Notably, the intensity of pain empathy elicited by these two social stimuli does not significantly differentiate the neural representations of social exclusion and separation, suggesting context-specific neural representations underlying these experiences. Furthermore, this study established a model that traces the progression from physiological pain to social pain empathy. In conclusion, this study revealed the neural pathological foundations and interconnectedness of empathy induced by social and physiological stimuli and provide robust neuromarkers to precisely evaluate empathy across physiological and social domains.

Keywords: fMRI; physiological pain empathy; social exclusion; social pain empathy; social separation.